Auriane destrument elucidating the role of mkk4 in neuronal apoptosis txt dating

16-Aug-2014 19:34

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auriane destrument elucidating the role of mkk4 in neuronal apoptosis-17

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Three genes, Whereas JNK1 and JNK2 expression is ubiquitous, JNK3 is predominantly expressed in the brain, testis, and heart.

However, this hypothesis could not apply to chicken embryonic fibroblasts (CEFs) in which the transforming activity of c-Jun inversely correlated with its transcriptional activity.

proposed that the oncogenic activity of v-Jun could result from its failure to activate the transcription of growth-attenuating genes that require high c-Jun activity.

Similar to JNK, MKK4 and MKK7 have both been implicated in mediating the apoptotic response of neurons to stress Therefore, it is possible that increased autophagy associated with the loss of JNK contributes to extending the life span of neurons in the developing brain.

JNK is also an essential component of stress-induced apoptosis in mouse embryonic fibroblasts (MEFs).

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